Jacob Parker

IDEAS - Computer Science and Physics

At the molecular level, a biological structure's physical behavior is an inherent product of the atomic environment that comprises it.  From this fundamental idea arises the relationship between a protein's function and its geometric shape.  My current work focuses on identifying potential RAS-effector proteins by algorithmically comparing subregional atomic configurations of Phosphoinositide 3-kinase, a well known RAS-effector, in complex with RAS G12V to all protein structures found in the Protein Data Bank.  Finding statistically significant matches is a major step in understanding the complex functional nature of proteins.

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